Ciliary Neurotrophic Factor
The polypeptide Ciliary Neurotrophic Factor (CNTF) is originally originating from chick embryo ocular tissure and considered as a trophic factor for embryonic chick ciliary parasympathetic neurons in science. Consecutive studies have shown CNTF's surviveability for even more neuronal cell types like dorsal root ganglion sensory neurons, sympathetic ganglion neurons, embryonic motor neurons, major pelvic ganglion neurons, and hippocampal neurons. Human CNTF and Rat CNTF yield nearly 83% homology in their protein sequences. CNTF is structurally related to IL-6, IL-11, LIF, and
OSM. These helix bundle cytokines have Glycoprotein 130 as a signal-transducing subunit in their receptor complexes.