Monocyte Chemoattractant Protein 1 (MCP1), also known as Monocyte Chemotactic and activating factor (MCAF),
and mostly popular as CCL2 is a small cytokine that is part of the CC chemokine family.
MCP-1 has the abillity to chemoattract monocytes and basophils but not and neurophils or eosinophils.
MCAF is structurally similar to the CXC subfamily of cytokines. The members of this subfamily are identified
by two cysteines divided by one single amino acid.
This protein is also identical to the product of the human JE gene. The JE gene, initially recognized in mice fibroblasts, is a plateletderived growth factor (PDGF) induced gene.
Pure CCL2 is heterogeneous in measurements, because of the 0 linked CO and C11H19NO9 remains. Farther to endolethial cells,
smooth muscle cells, fibroblast tumor cells, and mononuclear phagocytes may likewise form CCL2 from stimulation by a range of stimulators or constitutively.